Anti-UCHL1/PGP9.5 antibody

Product Name Anti-UCHL1/PGP9.5 antibody

Catalog No PAab09218

Packing 100ug

Form liquid

Alternative Name Neuron cytoplasmic protein 9.5 antibody, PARK5 antibody, PGP 9.5 antibody, PGP9.5 antibody, Ubiquitin thioesterase L1 antibody, Uch L1 antibody, UCHL1

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

UCHL1(Ubiquitin carboxyl-terminal hydrolase isozyme L1) is a member of a gene family whose products hydrolyze small C-terminal adducts of ubiquitin to generate the ubiquitin monomer. Expression of UCHL1 is highly specific to neurons and to cells of the diffuse neuroendocrine system and their tumors. It is present in all neurons(PMID: 6343558). This protein is present in brain at concentrations at least 50 times greater than in other organs and is a major protein component of neuronal cytoplasm (PMID:7217993). And UCHL1 is a Parkinson's disease susceptibility gene (PMID:15048890).

Immunogen ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

Specificity Human,Mouse ,Rat

Tested Application ELISA,WB,IP

Recommended dilution WB : 1:500-1:5000;IF