Anti-UXT antibody

Product Name Anti-UXT antibody

Catalog No PAab09353

Packing 100ug

Form liquid

Alternative Name ART 27 antibody, Protein UXT antibody, UXT

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor transcription (AR). AR N-terminus-associated coactivator which may play a role in facilitating receptor-induced transcriptional activation (PubMed:11854421). Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling (PubMed:11827465). Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC (PubMed:17554592). May be a nuclear chaperone that promotes formation of the NF-kappa-B enhanceosome and which is essential for its nuclear function (PubMed:17620405). Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM (PubMed:17635584). Together with URI1, associates with chromatin to the NKX3-1 promoter region.

Immunogen ubiquitously-expressed transcript

Specificity Human,Mouse ,Rat

Tested Application ELISA,WB,IP

Recommended dilution WB :1:200-1:1000;IP:1:200-1:1000

IHC use

WB use

HeLa cells were subjected to SDS PAGE followed by western blot with PAab09353(UXT antibody) at dilution of 1:400

Protein Information

Gene ID8409

Uniprot ID Q9UBK9

Calculated MW 18kDa

location