CXADR Antibody

Catalog  ABD6638    Packing 100ug

Reactivity with Human Mouse Rat

M.W.(Molecular Weight)  40kDa

Application  WB IHC

WB 1:500-1:2000 IHC 1:50-1:200

Western blot analysis of extracts of variouscell lines, using CXADR antibody.

Purification: Immunogen affinity purified 

Specificity: CXADR Antibody detects endogenous levels of total CXADR 

Immunogen: Recombinant protein of human CXADR 

CXADR Protein Information

Uniprot ID P78310

Description: The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21.

Function: Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair.(Microbial infection) Acts as a receptor for adenovirus type C (PubMed:9733828, PubMed:10666333, PubMed:12297051, PubMed:10567268). Acts as a receptor for Coxsackievirus B1 to B6 (PubMed:14978041, PubMed:10814575).

Subcellular Location: Extracellular region or secreted;Nucleus;Plasma Membrane;Other locations